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Corresponding author: Kerry J. Ressler; Email: kressle@emory.edu
Author contributions: R.A. and K.J.R. conceived and designed the study.
R.A. performed the behavioral experiments in mice, systemically injected SR-8993, and analyzed the data.
R.A. performed the micropunches and the mRNA isolation.
R.A. analyzed the microarray.
R.A. analyzed and performed the qPCR experiments.
R.A. performed stereotactic surgeries, intra-amygdala infusion of SR-8993, and histological experiments.
Y.T.C. and T.D.B. synthesized SR-8993.
M.C. performed and analyzed the pharmacokinetic experiments.
S.P.B. and H.S.-U. performed mouse behavior studies.
J.S.S. and T.J. performed and analyzed the fMRI experiments.
L.A. obtained the PSS data, and L.A. and K.J.R. analyzed the PSS data.
L.A. performed the genome-wide association studies, and L.A. and K.J.R. analyzed the data.
T.J. performed the FPS and analyzed the data.
K.J.R., S.P.B., T.J., T.D.B., B.B., E.B.B., and C.W. obtained the funding.
R.A. and K.J.R. wrote the manuscript.
We appreciate the technical assistance of G. Doho (Emory Cancer Genomics Shared Resource) with the microarray analyses.
We also thank M. Dierssen and A. Regi for sharing the software jTracks, which was used to analyze the water maze.
Competing interests: S.P.B., Y.T.C., H.S.-U., T.D.B., and C.W. have filed a patent related to this work: Provisional Patent Application Serial No. 61804316 “Substituted benzimidazoles as nociceptin receptor modulators” docket # 1361.184PV2.
The other authors declare that they have no competing interests.
This work was supported by NIH grants MH071537 (K.J.R.), MH096764 (K.J.R.), MH092576 (T.J.), and MH098212 (T.J.) as well as Brain and Behavior Research Foundation, the Burroughs Wellcome Fund, and Emory Medical Care Foundation (T.J.).
Support was received from the NIH/National Center for Research Resources base grant P51RR000165 to Yerkes National Primate Research Center.
The chemistry/new compound work was supported by the National Institute on Alcohol Abuse and Alcoholism (AA017943 to C.W., AA018665 to M.C.), the National Institute on Drug Abuse (DA035055 to C.W. and S.P.B., DA035056 to T.D.B.), and the National Center for Advancing Translational Sciences (UL1TR000454).
© 2013 by the American Association for the Advancement of Science; all rights reserved.