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Author Notes:
Correspondence: Kathy K. Griendling, Ph.D., Emory University School of Medicine, Division of Cardiology, 319 WMB, 1639 Pierce Dr., Atlanta, GA 30322; Phone: 404-727-3364; Fax: 404-727-3585; Email: kgriend@emory.edu
Subjects:
Research Funding:
This work was supported by NIH grants HL38206, HL075209, HL058000, and HL05863.
Keywords:
- Angiotensin II
- NADPH oxidases
- reactive oxygen species
- vascular
- kidney
- brain
NADPH Oxidases and Angiotensin II Receptor Signaling
Abstract:
Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin angiotensin system.
Copyright information:
© 2008 Elsevier Ireland Ltd. All rights reserved.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).
