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Correspondence and requests of materials should be addressed to C.H. (jchen@emory.edu)
The first two authors contributed equally to this work.
Author contributions T.H., L.Zhou, S.L., F.R.K., S.K., C.H. and J.C. designed this study. T.H. and J.F. performed experiments with help of S.E., H.-B.K., J.-H.S., and C.S. L.Zhou, L.Zhang and H.C. performed the crystallography experiments and data analysis with help of P.J and W.G. J.X., Y.W. and T.-L.G. performed the phospho-proteomics studies and generated the specific phospho-PGAM1 (pY26) antibody. M.A., G.L. and Y.K. performed mass spectrometry analysis. S.E., M.L.A, H.J.K., G.Z.C. and D.M.S. performed experiments to detect Y26 phosphorylation in human patient tissue samples. T.J.B. performed structural analysis. T.H., L.Zhou, S.K., C.H. and J.C. wrote the manuscript. All authors read and approved the final manuscript.
Acknowledgments: T.H. is a Fellow Scholar of the American Society of Haematology. J.X., Y.W. and T.-L.G. are employees of Cell Signaling Technology, Inc. G.Z.C., S.M.S., F.R.K., S.K. and J.C. are Georgia Cancer Coalition Distinguished Cancer Scholars. S. K. is a Robbins Scholar. S.K. and J.C. are American Cancer Society Basic Research Scholars. J.C. is a Scholar of the Leukaemia and Lymphoma Society.
Conflict of Interest The authors have declared that no conflict of interest exists.
This work was supported in part by NIH grants CA120272 (J.C.), CA140515 (J.C.), GM071440 (C.H.), DoD grant W81XWH-12-1-0217 (J.C.), the Pharmacological Sciences Training Grant T32 GM008602 (S.E.) and the National Natural Science Funds of China No. 20902013 (L.Zhou).
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