A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at risk psychiatric cohort

• Authors: Elisabeth B. Binder, Emory University; D. Jeffrey Newport, Emory University; Elizabeth B. Zach, Emory University; Alicia K Smith, Emory University; Todd C. Deveau, Emory University; Lori L. Altshuler, University of California; Lee S. Cohen, Massachusetts General Hospital; Zachary N Stowe, Emory University; Joseph F Cubells, Emory University
• Journal Title: Journal of Psychiatric Research
• Volume: Volume 44, Number 10
• Publisher: Elsevier | 2010-07, Pages 640-646
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.jpsychires.2009.12.001
• Keywords: peripartum depression; pregnancy; serotonin transporter; 5-HTTLPR; polymorphism; at risk population

Abstract

Backgroud Peripartum major depressive disorder (MDD) is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population. Methods 274 women with a prior history of MDD were genotyped for 5-HTTLPR and serially evaluated in late pregnancy (gestational weeks 31-40), early postpartum (week 1-8) and late postpartum (week 9-24) for diagnosis of a current major depressive episode (MDE) and depressive symptom severity. Results 5-HTTLPR S-allele carrier status predicted the occurrence of a MDE in the early postpartum period only (OR = 5.13, p = 0.017). This association persisted despite continued antidepressant treatment. Conclusions The 5-HTTLPR genotype may be a clinically relevant predictor of early postpartum depression in an at-risk population.