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Author Notes:
Address for correspondence: Dr. Jeff M. Sands, Emory University School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Room 338, Atlanta, GA 30322 USA, Phone: 404-727-2525, FAX: 404-727-3425, jeff.sands@emory.edu
Subject:
Research Funding:
Preview was supported by NIH grants R01-DK89828 and R21-DK91147
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Biochemistry & Molecular Biology
Urea Transporter Inhibitors: En Route to New Diuretics
Abstract:
A selective urea transporter UT-A1 inhibitor would be a novel type of diuretic, likely with less undesirable side effects than conventional diuretics, because it acts on the last portion of the nephron. In this issue of Chemistry & Biology, Esteva-Font and colleagues develop such an inhibitor by using a clever high-throughput screening assay and document its selectivity.
Copyright information:
© 2013 Elsevier Ltd.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
