Explaining individual variation in paternal brain responses to infant cries

• Authors: Ting Li, Emory University; Marilyn Horta, University of Florida; Jennifer Mascaro, Emory University; Kelly Bijanki, Emory University; Luc H. Arnal, University of Geneva; Melissa Adams, Emory University; Ronald G. Barr, British Columbia Children's Hospital; James K Rilling, Emory University
• Journal Title: Physiology and Behavior
• Volume: Volume 193, Number Pt A
• Publisher: Elsevier: 12 months | 2018-09-01, Pages 43-54
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.physbeh.2017.12.033
• Subjects: Biology, Neuroscience; Psychology, Behavioral; Anthropology, Medical and Forensic
• Keywords: Social Sciences; Science & Technology; Life Sciences & Biomedicine; Psychology, Biological; Behavioral Sciences; Psychology; Infant; Father; Cry; fMRI; ABUSIVE HEAD TRAUMA; MATERNAL-BEHAVIOR; POSTPARTUM DEPRESSION; ACOUSTIC FEATURES; OXYTOCIN; FMRI; QUESTIONNAIRE; INVENTORY; FATHERS; EMOTION

Abstract

Crying is the principal means by which newborn infants shape parental behavior to meet their needs. While this mechanism can be highly effective, infant crying can also be an aversive stimulus that leads to parental frustration and even abuse. Fathers have recently become more involved in direct caregiving activities in modern, developed nations, and fathers are more likely than mothers to physically abuse infants. In this study, we attempt to explain variation in the neural response to infant crying among human fathers, with the hope of identifying factors that are associated with a more or less sensitive response. We imaged brain function in 39 first-time fathers of newborn infants as they listened to both their own and a standardized unknown infant cry stimulus, as well as auditory control stimuli, and evaluated whether these neural responses were correlated with measured characteristics of fathers and infants that were hypothesized to modulate these responses. Fathers also provided subjective ratings of each cry stimulus on multiple dimensions. Fathers showed widespread activation to both own and unknown infant cries in neural systems involved in empathy and approach motivation. There was no significant difference in the neural response to the own vs. unknown infant cry, and many fathers were unable to distinguish between the two cries. Comparison of these results with previous studies in mothers revealed a high degree of similarity between first-time fathers and first-time mothers in the pattern of neural activation to newborn infant cries. Further comparisons suggested that younger infant age was associated with stronger paternal neural responses, perhaps due to hormonal or novelty effects. In our sample, older fathers found infant cries less aversive and had an attenuated response to infant crying in both the dorsal anterior cingulate cortex (dACC) and the anterior insula, suggesting that compared with younger fathers, older fathers may be better able to avoid the distress associated with empathic over-arousal in response to infant cries. A principal components analysis revealed that fathers with more negative emotional reactions to the unknown infant cry showed decreased activation in the thalamus and caudate nucleus, regions expected to promote positive parental behaviors, as well as increased activation in the hypothalamus and dorsal ACC, again suggesting that empathic over-arousal might result in negative emotional reactions to infant crying. In sum, our findings suggest that infant age, paternal age and paternal emotional reactions to infant crying all modulate the neural response of fathers to infant crying. By identifying neural correlates of variation in paternal subjective reactions to infant crying, these findings help lay the groundwork for evaluating the effectiveness of interventions designed to increase paternal sensitivity and compassion.