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Author Notes:

Gianluca Tosini: gtosini@msm.edu

SO, DB, CT, and GT wrote the paper; SO drew the figures.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subjects:

Research Funding:

This work was supported by grants from São Paulo Research Foundation (FAPESP) 2017/01882-8 to DB; National Institutes of Health (NIH) grant T-32 HL103104 to GT; and by 5U54NS083932, S21MD000101, G12-RR03034, U54RR026137 to Morehouse School of Medicine.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Endocrinology & Metabolism
  • melatonin
  • MT1
  • MT2
  • diabetes
  • leptin
  • FASTING PLASMA-GLUCOSE
  • BROWN ADIPOSE-TISSUE
  • FOOD-INTAKE
  • INSULIN SENSITIVITY
  • GENE POLYMORPHISMS
  • LEPTIN RESISTANCE
  • BODY-WEIGHT
  • MTNR1B
  • EXPRESSION
  • VARIANTS

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

Tools:

Journal Title:

Frontiers in Endocrinology

Volume:

Volume 10, Number JULY

Publisher:

, Pages 488-488

Type of Work:

Article | Final Publisher PDF

Abstract:

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions. In addition to its rather well-established roles in the regulation of circadian rhythms, sleep, and reproduction, melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that disruption of melatonin receptors signaling may contribute to the pathogenesis of type 2 diabetes, although the exact mechanisms underlying its action remain unclear. Additionally, a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy balance. This review summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism.

Copyright information:

© 2019 Owino, Buonfiglio, Tchio and Tosini.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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