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Author Notes:

Correspondence: Hans E. Grossniklaus MD, MBA, L.F. Montgomery Ophthalmic Pathology Laboratory, BT 428 Emory Eye Center, 1365 Clifton Road, Atlanta, GA 30322; Phone: 404-778-4611; Fax: 404-778-4610; Email: ophtheg@emory.edu.

Disclosures: The authors have no proprietary or commercial interest in any material discussed in this article.


Research Funding:

Supported in part by an unrestricted department grant from Research to Prevent Blindness, Inc., and NIH P30 EY06360.

Dr. Grossniklaus is a recipient of the Research to Prevent Blindness Senior Scientific Investigator Award.

Spectrum of CD30+ Lymphoid Proliferations in the Eyelid: Lymphomatoid Papulosis, Cutaneous Anaplastic Large Cell Lymphoma, and Anaplastic Large Cell Lymphoma


Journal Title:



Volume 117, Number 2


, Pages 343-351

Type of Work:

Article | Post-print: After Peer Review


Purpose: To report the clinicopathologic features of three patients with CD30+ lymphoid proliferations of the eyelid. Design: Retrospective case series. Participants: Patients with cutaneous CD30+ lymphoproliferative lesions of the eyelid. Methods: Three patients with CD30+ non-mycosis fungoides T cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments and outcomes were reviewed and compared. Main Outcome Measures: Pathologic findings including immunohistochemical analysis. Results: The patients included an 81-year-old man, an 18-year-old man, and a 42-year-old woman, with CD30+ lymphoid proliferations of the eyelid and adjacent soft tissue. The first patient had an isolated crateriform eyelid lesion that was classified as lymphomatoid papulosis (LyP). The second patient had an isolated multinodular lesion of the eyelid that was classified as cutaneous anaplastic large cell lymphoma (cALCL). The third patient presented with eyelid edema with an underlying mass and was found to have widely disseminated anaplastic large cell lymphoma (ALCL). Diagnoses were dependent on clinical findings. Conclusions: CD30+ lymphoid proliferations represent a spectrum of conditions ranging from indolent LyP, to moderately aggressive cALCL, and to highly aggressive ALCL. Interpretation of the pathologic findings in CD30+ lymphoid proliferations is based in part on clinical findings.

Copyright information:

© 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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