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Author Notes:

Corresponding author: Gretchen N Neigh, Department of Psychiatry and Behavioral Sciences, Emory University, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA. Email: gretchen.neigh@emory.edu.

Gretchen N Neigh, PhD, receives research funding from NARSAD, AHA, NIH, and GlaxoSmithKline.

Michael J Owens, PhD, receives research funding from NIH, Eli Lilly, Lundbeck, Cyberonics, Ortho-McNeil Janssen, AstraZeneca, and Dainippon Sumitomo. Dr Owens consults for H Lundbeck A/S.

Charles B Nemeroff, MD, PhD, has research funding from NIH, is on the Scientific Advisory Board for AFSP, AstraZeneca, Forest Laboratories, NARSAD, Quintiles, Janssen/Ortho-McNeil, PharmaNeuroboost, and Mt Cook Pharma; is a stockholder in Corcept, Revaax, NovaDel Pharma, CeNeRx, and PharmaNeuroboost; and is on the Board of directors for American Foundation for Suicide Prevention (AFSP), George West Mental Health Foundation, NovaDel Pharma, and Mt Cook Pharma.

Dr Nemeroff and Dr Owens have a patent entitled ‘A method to estimate transporter occupancy.'

Dr Nemeroff has a patent on the method and devices for transdermal delivery of lithium (US 6,375,990 B1).

Subjects:

Keywords:

  • angiogenesis
  • anhedonia
  • dexamethasone
  • prenatal stress
  • vascular

Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress

Tools:

Journal Title:

Journal of Cerebral Blood Flow and Metabolism

Volume:

Volume 30, Number 6

Publisher:

, Pages 1100-1104

Type of Work:

Article | Post-print: After Peer Review

Abstract:

In addition to the neuronal and behavioral consequences of excess glucocorticoid exposure, the cerebrovascular system can also be adversely affected by stressors. This study determined that chronic stress in adulthood decreased the vascular area fraction of the hippocampus and increased the vascular area fraction of the amygdala. In addition, the data indicated that prenatal exposure to synthetic glucocorticoids modulated the effects of adult stress on vascular area fraction of the hippocampus and amygdala. These data indicate that in addition to the well-documented stress-induced changes in neurons and glia, cerebral vasculature is also altered by exposure to stressors.

Copyright information:

© 2010 Nature Publishing Group

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