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Author Notes:

Correspondence: David C Neujahr, M.D., 1364 Clifton Rd Suite Rd Suite F520, Atlanta GA; Email: David.neujahr@emoryhealthcare.org

Acknowledgments: The authors wish to thank Drs Allan Ramirez and Andres Pelaez for assistance with sample collection.

Disclosures: The authors of this manuscript have no conflicts of interest to disclose

Subject:

Research Funding:

David C. Neujahr is supported by a grant from the Roche Organ Transplant Research Foundation and by an NIH Career Development Award (K08AI079166).

The investigators wish to thank the Atlanta Clinical and Translational Science Institute and the Emory Transplant Center Biorepository for supporting this research.

Keywords:

  • Lung Transplantation
  • rejection
  • granzyme B
  • FEV1

Cumulative Exposure to CD8+ Granzyme Bhi T cells Is Associated With Reduced Lung Function Early after Lung Transplantation

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Journal Title:

Transplantation Proceedings

Volume:

Volume 43, Number 10

Publisher:

, Pages 3892-3898

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Outcomes following lung transplant remain suboptimal. This is attributable to variable post-transplant recovery of lung function, and inconsistent degrees of lung function loss after peak function is reached. Granzyme B is elevated in the blood and bronchoalveolar lavage (BAL) in acute rejection. We hypothesized that persistent exposure to T cells high in granzymeB would negatively correlate with lung function. We investigated cumulative exposure measured as the area-under-the-curve (AUC) of CD8+ T cell granzyme Bhi cells in the first year post transplant in both BAL and blood in 24 transplant recipients. We assessed the correlation between cumulative 1-year exposure and FEV1 slope. There was a negative correlation between 1-year exposure and FEV1 slope within the first year (r−.63, p.001). This relationship persisted even when adjusted for transplant type, gender, age, rejection, and indication for transplantation. In contrast, no relationship was seen with the 1-year AUC and lung function after 1 year post transplant. In contrast to the BAL granzyme B hi levels, granzyme B hi levels from the blood showed no relationship with lung function. These findings suggest that CD8+ T cell driven factors are responsible for early improvements in lung function after transplantation.

Copyright information:

© 2011 Elsevier Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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