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Author Notes:

Correspondence: Anapatricia Garcia D.V.M., Ph.D., Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA, Department of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA, agarci5@emory.edu, Ruth M. Ruprecht, M.D., Ph.D., Dana-Farber Cancer Institute, Boston, Massachusetts, USA, Harvard Medical School, Boston, Massachusetts, USA, Ruth_Ruprecht@dfci.harvard.edu

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Research Funding:

The work was supported by NIH grants R56 AI062515 to R.M.R., PO1 AI 048240 to R.M.R. and J.G.E., and base grant RR-000165 to the Yerkes National Primate Research Center.

Keywords:

  • R5 SHIV
  • neuroAIDS
  • optic neuropathy

AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

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Journal Title:

Journal of Medical Primatology

Volume:

Volume 39, Number 5

Publisher:

, Pages 356-360

Type of Work:

Article | Post-print: After Peer Review

Abstract:

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy, and a focus of infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

Copyright information:

© 2010 John Wiley & Sons A/S

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