The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo

• Authors: Hui Ren, Emory University; Mingwei Chen, Jiaotong University; Ping Yue, Emory University; Hui Tao, Emory University; Taofeek K Owonikoko, Emory University; Suresh S Ramalingam, Emory University; Fadlo Khuri, Emory University; Shi-Yong Sun, Emory University
• Journal Title: Cancer Letters
• Volume: Volume 325, Number 2
• Publisher: Elsevier: 12 months | 2012-12-28, Pages 139-146
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.canlet.2012.06.018
• Subjects: Health Sciences, Oncology
• Keywords: RAD001; BKM120; PI3 kinase; mTOR; lung cancer

Abstract

This study focuses on determining whether the combination of NYP-BKM120 (BKM120) and RAD001 exerts enhanced therapeutic effect against lung cancer. The combination of BKM120 and RAD001 exerted synergistic inhibitory effects on the growth of lung cancer cells both in culture and in mouse xenograft model. This combination abrogated RAD001-induced Akt phosphorylation and exerted enhanced suppressive effect on 4EBP1 phosphorylation. Collectively, we suggest that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic.