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Author Notes:
David Weinshenker, PhD, Department of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St., Atlanta, GA 30322, Phone: (404) 727-3106, Fax: (404) 727-3949, dweinsh@emory.edu.
We thank Yvonne Ogbonmwan (Department of Human Genetics, Emory University); and the laboratory of Dr. Stephen Warren for technical assistance.
Subjects:
Research Funding:
These experiments were supported by the National Institute of Drug Abuse (DA027535 to DW); and the National Institute of Neurological Disease and Stroke (NS065663 to SAE).
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Behavioral Sciences
- Clinical Neurology
- Psychiatry
- Neurosciences & Neurology
- Epilepsy
- Depression
- Comorbidity
- Rat
- Animal model
- Exercise
- Antidepressant
- Anticonvulsant
- Galanin
- Locus coeruleus
- TEMPORAL-LOBE EPILEPSY
- MESSENGER-RNA LEVELS
- PHYSICAL-EXERCISE
- LOCUS-COERULEUS
- SWIM-TEST
- ELECTROENCEPHALOGRAPHIC RESPONSES
- HIPPOCAMPAL NEUROGENESIS
- VOLUNTARY EXERCISE
- INDUCED SEIZURES
- GALANIN
Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity
Abstract:
The bidirectional comorbidity between epilepsy and depression is associated with severe challenges for treatment efficacy and safety, often resulting in poor prognosis and outcome for the patient. We showed previously that rats selectively bred for depression-like behaviors (SwLo rats) also have increased limbic seizure susceptibility compared with their depression-resistant counterparts (SwHi rats). In this study, we examined the therapeutic efficacy of voluntary exercise in our animal model of epilepsy and depression comorbidity. We found that chronic wheel running significantly increased both struggling duration in the forced swim test and latency to pilocarpine-induced limbic motor seizure in SwLo rats but not in SwHi rats. The antidepressant and anticonvulsant effects of exercise were associated with an increase in galanin mRNA specifically in the locus coeruleus of SwLo rats. These results demonstrate the beneficial effects of exercise in a rodent model of epilepsy and depression comorbidity and suggest a potential role for galanin.
Copyright information:
© 2013 Elsevier Inc.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
