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Author Notes:

Corresponding authors: anil.mehta@emory.edu; lary.walker@emory.edu; david.lynn@emory.edu.

We are grateful to Jeannette Taylor and Hong Yi in the Emory Robert P. Apkarian Microscopy Core for TEM advice and training.

Subjects:

Research Funding:

The authors acknowledge NSF and the NASA astrobiology Program, under the NSF Center for Chemical Evolution CHE-1004560.

The Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy through Grant DE-ER15377 for structural analyses.

This work also was supported in part by NIH R21AG040589, P51RR165, P51OD11132, P01AG026423, P50AG025688, the Coins for Alzheimer's Research Trust (CART) Foundation and the Australian Research Council Future Fellow FT0991558 program.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Biophysics
  • amyloid
  • PIB
  • amyloid strains
  • nanotubes
  • NMR spectrsocopy
  • BETA-AMYLOID FIBRILS
  • ALZHEIMER A-BETA
  • EXPERIMENTAL CONSTRAINTS
  • MEMBRANE INTERACTIONS
  • COGNITIVE IMPAIRMENT
  • EXOGENOUS INDUCTION
  • CHEMICAL-SHIFTS
  • AMINO-ACIDS
  • IN-VIVO
  • TRANSMISSION

Context Dependence of Protein Misfolding and Structural Strains in Neurodegenerative Diseases

Tools:

Journal Title:

Biopolymers

Volume:

Volume 100, Number 6

Publisher:

, Pages 722-730

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Vast arrays of structural forms are accessible to simple amyloid peptides and environmental conditions can direct assembly into single phases. These insights are now being applied to the aggregation of the Aβ peptide of Alzheimer's disease and the identification of causative phases. We extend use of the imaging agent Pittsburgh compound B to discriminate among Aβ phases and begin to define conditions of relevance to the disease state. Also, we specifically highlight the development of methods for defining the structures of these more complex phases.

Copyright information:

© 2013 Wiley Periodicals, Inc.

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