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Author Notes:

*Co-Corresponding Authors: Winship Cancer Institute, Emory University, 1365C Clifton Rd NE, Atlanta, GA 30322, USA, Ph: 404-778-5563, Fax: 404-778-5550, chadjip@emory.edu, evanmei@emory.edu

Contributor Information Edjah Kweku-Ebura Nduom, Department of Neurosurgery, Emory University School of Medicine.

Costas George Hadjipanayis, Department of Neurosurgery, Emory University School of Medicine; Georgia Cancer Coalition Distinguished Scholar; Director, Emory Brain Tumor Nanotechnology Laboratory, Winship Cancer Institute of Emory University.

Erwin G. Van Meir, Departments of Neurosurgery and Hematology and Medical Oncology, Emory University School of Medicine; Leader, Winship Cancer Institute Cancer Cell Biology Program; Director, Emory Graduate Program in Cancer Biology; Director, Laboratory of Molecular Neuro-Oncology.

Subject:

Research Funding:

The authors would like to acknowledge The National Institutes of Health, The National Institute of Neurological Disorders and Stroke, The Dana Foundation and The Georgia Cancer Coalition for their support.

Keywords:

  • Glioblastoma
  • stem cells
  • gliomagenesis
  • brain tumors
  • GBM
  • cancer stem cells
  • CNS tumors

Glioblastoma Cancer Stem-like Cells – Implications for Pathogenesis and Treatment

Tools:

Journal Title:

Cancer Journal

Volume:

Volume 18, Number 1

Publisher:

, Pages 100-106

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Glioblastoma remains one of the deadliest forms of cancer. Infiltrating cancer cells in the surrounding brain prevent complete resection and tumor cell resistance to chemoradiation results in the poor prognosis of the glioblastoma patient. Much research has been devoted over the years to the pathogenesis and treatment of glioblastoma. The tumor stem cell hypothesis, which was initially described in hematopoietic cell malignancies, may explain the resistance of these tumors to conventional therapies. In this model, a certain subset of tumor cells, with characteristics similar to normal neural stem cells, is capable of producing the variety of cell types, which constitute the bulk of a tumor. As these tumor cells have properties distinct from those constituting the bulk of the tumor, a different approach may be required to eradicate these residual infiltrating cells from the brain. Here we outline the history behind the theory of glioblastoma cancer stem-like cells, as they are now referred to. We will also discuss the implications of their existence on commonly held beliefs about glioblastoma pathogenesis and how they might influence future treatment strategies.
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