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Author Notes:

Correspondence: Diana I. Simeonova, Dipl.-Psych., Ph.D., Child and Adolescent Mood Program, Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, 1256 Briarcliff Road NE, Suite 312E, Atlanta, GA 30306; Tel: (404) 727-1910; Fax: (404) 727-3421; Email: dsimeon@emory.edu

Authors' Contributions: Each of the contributors has made a substantial contribution to the research and the preparation of the manuscript: Diana I. Simeonova, Dipl.-Psych., Ph.D., Ashraf Attalla, M.D., Hanan Trotman, Ph.D., Michelle Esterberg, M.A., and Elaine F. Walker, Ph.D.

Acknowledgments: The authors wish to thank Dr. W. Edward Craighead for his support during the preparation of this manuscript.

Disclosures: The authors have no conflicts of interest to report.

Subject:

Research Funding:

This research was supported in part by NIMH Predoctoral Research Fellowship T-32 MH073525-01 (Dr. Diana I. Simeonova) and R01 MH4062066 (Dr. Elaine F. Walker).

Keywords:

  • Psychosis
  • Prodromal
  • High-Risk
  • Adolescents
  • Social Functioning
  • Behavioral Problems

Does a Parent-Report Measure of Behavioral Problems Enhance Prediction of Conversion to Psychosis in Clinical High-Risk Adolescents?

Tools:

Journal Title:

Schizophrenia Research

Volume:

Volume 130, Number 1-3

Publisher:

, Pages 157-163

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present study, a widely used parent-report measure of behavioral problems, the Child Behavior Checklist (CBCL) was administered to examine the clinical and diagnostic utility of the measure as an adjunctive screening instrument in the identification of at-risk youth. The CBCL, the Structured Interview for Prodromal Syndromes (SIPS), and other diagnostic measures were administered at baseline and at one year follow-up assessments to adolescents (n = 41) at clinical high-risk for the development of a psychotic disorder. Analyses were conducted to compare the 14 at-risk adolescents who subsequently converted to psychosis to the 27 who did not. Conversion to psychosis was defined as conversion to an Axis I psychotic disorder or affective disorder with psychotic features. Consistent with expectations, at one year follow-up, compared to the Non-Converted participants, the Converted participants manifested significantly higher scores on the prodromal symptom scales of the SIPS. There were, however, no differences in CBCL social and behavioral ratings as a function of conversion status. It is concluded that the CBCL does not show promise as an alternative or adjunctive predictor of conversion to psychosis in at-risk adolescents.

Copyright information:

© 2011 Elsevier B.V. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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