About this item:

752 Views | 151 Downloads

Author Notes:

Correspondence: Donald L. Bliwise, Ph.D., Department of Neurology, Emory University School of Medicine, 1841 Clifton Road, Room 509, Atlanta, Georgia 30329; Phone: 404-728-4751; Fax: 404-712-8145; Email: dbliwis@emory.edu.

Acknowledgments: Some patients were recruited from the Parkinson Progression Markers Initiative.

Disclosures: Bliwise is a consultant for Ferring.

Trotti is a consultant for UCB.

Factor is a consultant for Boehringer Ingelheim, Merz, and Ipsen; receives royalties from Demos and Blackwell Futura; and is a paid editor for Current Treatment Options in Neurology and Current Neurology and Neuroscience.

Freeman serves on the advisory board for Metz, Ipsen, Allergan, and UCB.

Rye is a consultant for UCB and Merck.


Research Funding:

This work was supported by R01 NS-050595 (DLB); UL1 RR-025008/KL2 RR-025009 (Atlanta Clinical and Translational Science Institute); and U01 NS-050324 (CoQ10 trial).

Juncos has received grants from Chelsea and Allon.

Factor has received grants from TEVA, EMD Serono, Ipsen, Ceregene, Allergan, and Medtronics.

Freeman has received grants from EMD Serono and Phytopharm.


  • Parkinson’s Disease
  • Narcolepsy
  • REM Sleep

Daytime REM sleep in Parkinson's disease


Journal Title:

Parkinsonism and Related Disorders


Volume 19, Number 1


, Pages 101-103

Type of Work:

Article | Post-print: After Peer Review


Background: Previous studies have demonstrated both clinical and neurochemical similarities between Parkinson’s disease (PD) and narcolepsy. The intrusion of REM sleep into the daytime remains a cardinal feature of narcolepsy, but the importance of these intrusions in PD remains unclear. In this study we examined REM sleep during daytime Maintenance of Wakefulness Testing (MWT) in PD patients. Methods: Patients spent 2 consecutive nights and days in the sleep laboratory. During the daytime, we employed a modified MWT procedure in which each daytime nap opportunity (4 per day) was extended to 40 minutes, regardless of whether the patient was able to sleep or how much the patient slept. We examined each nap opportunity for the presence of REM sleep and time to fall asleep. Results: Eleven of 63 PD patients studied showed 2 or more REM episodes and 10 showed 1 REM episode on their daytime MWTs. Nocturnal sleep characteristics and sleep disorders were unrelated to the presence of daytime REM sleep, however, patients with daytime REM were significantly sleepier during the daytime than those patients without REM. Demographic and clinical variables, including Unified Parkinson’s Disease Rating Scale motor scores and levodopa dose equivalents, were unrelated to the presence of REM sleep. Conclusions: A sizeable proportion of PD patients demonstrated REM sleep and daytime sleep tendency during daytime nap testing. These data confirm similarities in REM intrusions between narcolepsy and PD, perhaps suggesting parallel neurodegenerative conditions of hypocretin deficiency.

Copyright information:

© 2012 Elsevier Ltd. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Creative Commons License

Export to EndNote