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Author Notes:

Correspondence: Daniel Kalman, Microbiology and Molecular Genetics Program, Emory University, Atlanta, Georgia, USA 30322; Email: dkalman@emory.edu

Acknowledgments: We regret that space limitations precluded citation of all the work in this area.

We are grateful to the members of the Kalman and Romeo labs for helpful discussions.

Subjects:

Research Funding:

Work in our lab is supported by grants from the National Institute of Health - R01DK074731-01 and R01A1056067-01 (to D.K.) and R01-GM059969 (to T.R.). S.B is a recipient of the National Science Foundation award 0450303 subaward I-66-606-63 to Emory University.

Honing the message: posttranscriptional and posttranslational control in attaching and effacing pathogens

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Journal Title:

Trends in Microbiology

Volume:

Volume 19, Number 5

Publisher:

, Pages 217-224

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Bacteria evolve their capacity to cause disease by acquiring virulence genes that are usually clustered in discrete genetic modules termed pathogenicity islands (PAI). Stable integration of PAIs into preexisting transcriptional networks coordinates expression from PAIs with ancestral genes in response to diverse environmental cues. Such transcriptional controls are evident in the regulation of the locus of enterocyte effacement (LEE), a PAI of enteropathogenic and enterohemorrhagic Escherichia coli. However, recent reports indicate that global posttranscriptional and posttranslational regulators, including CsrA, Hfq and ClpXP, fine-tune the transcriptional output from the LEE. Here, we highlight recent advances in understanding posttranscriptional and posttranslational regulation in attaching and effacing pathogens.

Copyright information:

© 2011, Elsevier

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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