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Author Notes:

Corresponding Author: Christian P. Larsen, Professor and Chair, Dept of Surgery, 101 Woodruff Circle, WMB Suite 5105, Emory University, Atlanta, GA 30322, 404-727-8465 (Ph), 404-727-3660 (Fax), clarsen@emory.edu

Subject:

Research Funding:

National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID

This work was supported by N01 AI050025 to C.P.L.

Keywords:

  • mTOR
  • CD8+ T-lymphocyte
  • vaccine

Sirolimus enhances the magnitude and quality of viral-specific CD8+ T cell responses to vaccinia virus vaccination in rhesus macaques

Tools:

Journal Title:

American Journal of Transplantation

Volume:

Volume 11, Number 3

Publisher:

, Pages 613-618

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Sirolimus is a potent anti-proliferative agent used clinically to prevent renal allograft rejection. However, little is known about the effects of maintenance immunosuppressive agents on the immune response to potentially protective vaccines. Here we show that sirolimus paradoxically increases the magnitude and quality of the CD8+ T cell response to vaccinia vaccination in non-human primates, fostering more robust recall responses compared to untreated and tacrolimus-treated controls. Enhancement of both the central and effector memory compartments of the vaccinia-specific CD8+ T cell response was observed. These data elucidate new mechanistic characteristics of sirolimus and suggest immune applications extending beyond its role as an immunosuppressant.

Copyright information:

©2011 The Authors Journal compilation ©2011 The American Society of Transplantation and the American Society of Transplant Surgeons

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