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Author Notes:

Correspondence: Benjamin M. Hampstead, Ph.D., 1441 Clifton Rd NE Room 150, Atlanta, GA 30087; Phone: 404-712-5667, Fax: 404-712-1652, Email: bhampst@emory.edu

Authors' Contributions: Each author provided significant intellectual contribution to warrant authorship and declares that he/she has seen and approved this manuscript.

Dr. Benjamin M. Hampstead had full access to all the data in the study; he and Dr. K. Sathian had final responsibility for the decision to submit for publication.

_We wish to thank Dr. Pamela Phillips for her assistance with participant recruitment and testing_

Disclosures: No author has any conflict of interest.

The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government.


Research Funding:

This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and Rehabilitation Research and Development Service through grants B6366W to BMH and VA Merit B6662R to KS and by the Emory Alzheimer’s Disease Research Center (NIA: 2P50AG025688).

Support to KS from the National Institutes of Health (NIH) grant K24 EY017332 is also acknowledged. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government.

Mnemonic strategy training partially restores hippocampal activity in patients with mild cognitive impairment


Journal Title:



Volume 22, Number 8


, Pages 1652-1658

Type of Work:

Article | Post-print: After Peer Review


Learning and memory deficits typify patients with mild cognitive impairment (MCI) and are generally attributed to medial temporal lobe dysfunction. Although the hippocampus is perhaps the most commonly studied neuroanatomical structure in these patients, there have been few attempts to identify rehabilitative interventions that facilitate its functioning. Here, we present results from a randomized, controlled, single-blind study in which patients with MCI and healthy elderly controls (HEC) were randomized to either 3 sessions of mnemonic strategy training (MS) or a matched-exposure control group (XP). All participants underwent pre- and post-training fMRI scanning as they encoded and retrieved object-location associations. For the current report, fMRI analyses were restricted to the hippocampus, as defined anatomically. Before training, MCI patients showed reduced hippocampal activity during both encoding and retrieval, relative to HEC. Following training, the MCI MS group demonstrated increased activity during both encoding and retrieval. There were significant differences between the MCI MS and MCI XP groups during retrieval, especially within the right hippocampus. Thus, MS facilitated hippocampal functioning in a partially restorative manner. We conclude that cognitive rehabilitation techniques may help mitigate hippocampal dysfunction in MCI patients.

Copyright information:

© 2012 Wiley Periodicals, Inc.

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