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Author Notes:

Correspondence should be addressed to S.S.D. (sandeep.dave@duke.edu)

C.L., R.M., K.L.R., C.H.D., W.W.L.C., G.S., P.L.L., D.A.R., A.S.L., L.B.-M., K.P.M., C.R.F., K.N.N., A.M.E., A.C., L.I.G., M.B.C., J.I.G., E.D.H., J.Z., G.L., A.G., M.M., S.L. and S.S.D. performed research and edited the manuscript.

C.L., J.Z., A.B.M., D.J., Z.S., V.G., A.B., D.B.D. and S.S.D. analyzed data.

C.L. and S.S.D. wrote the manuscript.

The authors thank S. Sunay and the Georgia Cancer Coalition for support in sample collection.

We gratefully acknowledge the generous support of C. Stiefel and D. Stiefel.

The authors declare no competing financial interests.

Subject:

Research Funding:

A.B.M. was supported by the Hertz Foundation.

This work was supported through grants R21CA1561686 and R01CA136895 from the National Cancer Institute (S.S.D.).

S.S.D. was also supported by the American Cancer Society.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Genetics & Heredity
  • C-MYC ONCOGENE
  • SOMATIC MUTATIONS
  • GENOME
  • CANCER
  • EXPRESSION
  • AMPLIFICATION
  • FREQUENT
  • REVEALS

The genetic landscape of mutations in Burkitt lymphoma

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Journal Title:

Nature Genetics

Volume:

Volume 44, Number 12

Publisher:

, Pages 1321-1325

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.

Copyright information:

© 2012 Nature America, Inc. All rights reserved.

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