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Author Notes:

Correspondence: Bruce Crosson, Ph.D., VA RR&D Center of Excellence (151R), Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033; bruce.crosson@emory.edu; Phone: 404-728-5064; FAX: 404-728-4837.

The authors wish to acknowledge Floris Singletary for her assistance in recruitment of subjects for the current study and to recognize JoEllen Gilbert and Cecilia Brooks for providing the therapies to subjects in Jacksonville.

The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government.


Research Funding:

This research was funded by Grants R01DC007387 (BC) and K23 DC010197 (JJR) from the National Institute on Deafness and Other Communication Disorders; Senior Research Career Scientist Award B6364L (BC), Research Career Scientist Award B5083L (LJGR), and Center of Excellence Award B3149C (LJGR) from the VA Rehabilitation Research & Development Service.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Rehabilitation
  • Neurosciences & Neurology
  • aphasia
  • magnetic resonance imaging
  • fMRI
  • rehabilitation
  • rehabilitation of speech and language disorders
  • neuronal plasticity
  • TMS

A Behavioral Manipulation Engages Right Frontal Cortex During Aphasia Therapy

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Journal Title:

Neurorehabilitation and Neural Repair


Volume 28, Number 6


, Pages 545-553

Type of Work:

Article | Post-print: After Peer Review


Background. An aphasia treatment was designed to shift laterality from the left to right lateral frontal lobe during word production by initiating word-finding trials with complex left-hand movements. Previous findings indicated successful relateralization. Objective. The current study was designed to ascertain whether the shift was attributable to the lefthand movement. Methods. Using stratified random sampling, 14 subjects were equally divided between Intention (IT) and Control (CT) treatments. CT was identical to IT, except with no left-hand movements. Both treatments trained picture naming (phases 1 and 2) and category-member generation (phase 3), each phase lasting 10 sessions. Functional magnetic resonance imaging of category member generation occurred at pretreatment, posttreatment, and 3-month follow-up. Results. IT shifted lateral frontal activity rightward compared with pretreatment both at posttreatment (t = -2.602, df = 6, P < .05) and 3-month follow-up (t = -2.332, df = 5, P < .05), but CT did not. IT and CT yielded similar changes for all picture-naming and category probes. However, IT patients showed gains for untrained category (t = 3.33, df = 6, P < .01) and picture-naming probes (t = 3.77, df = 5, P < .01), but CT patients did not. Conclusions. The rightward shift in lateral frontal activity for IT was because of the left-hand movements. IT evoked greater generalization than CT.

Copyright information:

© The Author(s) 2013.

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