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Author Notes:

Corresponding Author: Benjamin M. Hampstead, Ph.D., 1441 Clifton Rd NE Room 150, Atlanta, GA 30087, 404-712-5667 (office), 404-712-1652 (fax), bhampst@emory.edu

Author Contributions Each author provided significant intellectual contribution to warrant authorship and declares that he/she has seen and approved this manuscript.

Dr. Benjamin M. Hampstead had full access to all the data in the study and had final responsibility for the decision to submit for publication.

The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government.

Portions of this work were presented at the annual meetings of the International Neuropsychological Society (2010) and the American Academy of Clinical Neuropsychology (2011).


Research Funding:

This material is based upon work supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and Rehabilitation Research and Development Service through grants B4602H & B6366W to BMH and VA Merit B6662R to KS.

This work was also funded through the Emory Alzheimer’s Disease Research Center (NIA: 2P50AG025688) and support to KS from the National Institutes of Health (NIH) grant K24 EY017332.

This study was registered with the National Clinical Trials database (NCT00714571).


  • cognitive rehabilitation
  • associative memory
  • MRI
  • hippocampal volume
  • aging

Mnemonic strategy training improves memory for object location associations in both healthy elderly and patients with amnestic mild cognitive impairment: a randomized, single-blind study


Journal Title:



Volume 26, Number 3


, Pages 385-399

Type of Work:

Article | Post-print: After Peer Review


Objectives To evaluate the efficacy of mnemonic strategy training versus a matched-exposure control condition and also to examine the relationship between training-related gains, neuropsychological abilities, and medial temporal lobe volumetrics in patients with amnestic mild cognitive impairment (aMCI) and age-matched healthy controls. Methods Twenty-three of 45 screened healthy controls and 29 of 42 screened aMCI were randomized to mnemonic strategy or matched-exposure groups. Groups were run in parallel, with participants blind to the other intervention. All participants completed five sessions within two weeks. Memory testing for object-location associations was performed during sessions one and five and at a one-month follow-up. During sessions 2–4, participants received either mnemonic strategy training or a matched number of exposures with corrective feedback for a total of 45 object-location associations. Structural MRI was performed in most participants and medial temporal lobe volumetrics were acquired. Results Twenty-one healthy controls and 28 aMCI patients were included in data analysis. Mnemonic strategy training was significantly more beneficial than matched-exposure immediately after training, p =.006, pη2 = .16, and at one month, p<.001, pη2 = .35, regardless of diagnostic group (healthy controls or aMCI). Although aMCI patients demonstrated gains comparable to the healthy control groups, their overall performance generally remained reduced. Mnemonic strategy-related improvement was positively correlated with baseline memory and executive functioning and negatively with inferior lateral ventricle volume in aMCI patients; no significant relationships were evident in matched-exposure patients. Conclusions Mnemonic strategies effectively improve memory for specific content for at least one month in aMCI.

Copyright information:

©2014 American Psychological Association

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