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Author Notes:

Corresponding Author: Andrew Escayg, Ph.D., Emory University School of Medicine, Department of Human Genetics, 615 Michael Street, Whitehead Building, Suite 301, Atlanta, Georgia 30322, Telephone number: (404) 712-8328, Fax number: (404) 727-3949, E-mail: aescayg@genetics.emory.edu

We will like to thank Drs. Karin Borges, Adam Hartman, Kristopher Bough and David Weinshenker for valuable advice.

We will also like to thank Cheryl Strauss for critically reading the manuscript.

We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Disclosure: The authors declare no conflicts of interest.

Subjects:

Research Funding:

This work is supported by NIH Research Grant NS046484 (A.E.).

Keywords:

  • ketogenic diet
  • sodium channel
  • SCN1A
  • severe myoclonic epilepsy of infancy
  • animal models
  • epilepsy

Genetic influences on ketogenic diet efficacy

Tools:

Journal Title:

Epilepsia

Volume:

Volume 49, Number Suppl 8

Publisher:

, Pages 67-69

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Summary An average of 15–20% of patients on the ketogenic diet (KD) experience a >50% reduction in seizure frequency; however, 10–40% discontinue the diet due to either a lack of response or adverse side effects. This variability in patient response raises the possibility that genetic factors may influence the efficacy of the KD. As a first step towards identifying these factors, we evaluated the ability of the KD to alter seizure thresholds in 4 commonly used inbred mouse strains: C57BL/6J, FVB/NJ, A/J, and DBA/2J. We observed strain-specific differences, indicating that genetic factors are likely to influence efficacy.

Copyright information:

© 2008 International League Against Epilepsy

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