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Author Notes:

Correspondence may be sent to Felicia C. Goldstein, Ph.D., Neurology Department, Wesley Woods Health Center, 1841 Clifton Road, N.E., Atlanta, Georgia 30329. E-mail: fgoldst@emory.edu

Contributor Information Felicia C. Goldstein, Department of Neurology, Emory University School of Medicine.

Angela V. Ashley, Department of Neurology, Emory University School of Medicine.

Yohannes Endeshaw, Department of Geriatric Medicine, Emory University School of Medicine.

John Hanfelt, Department of Biostatistics, Emory University School of Medicine. James J. Lah, Department of Neurology, Emory University School of Medicine.

Allan I. Levey, Department of Neurology, Emory University School of Medicine.

Acknowledgments: We thank Vanessa Garner, RN, Janet Cellar, RN, Andrea J. Kippels, RN, Kerry Ann Kelly, B.A., and Tara Ravichandran, B.A. for their help in recruiting and evaluating patients.

Portions of the research were presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, Oregon, February 2007.

Subject:

Research Funding:

National Institute on Aging : NIA

This research was supported by the Senator Mark Hatfield Award from the Alzheimer’s Association and The Emory Alzheimer’s Disease Research Center (NIH-NIA 5 P50 AG025688).

Keywords:

  • Alzheimer’s Disease
  • Hypertension
  • Hypercholesterolemia
  • Cognitive Functioning

Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients with Alzheimer’s Disease

Tools:

Journal Title:

Alzheimer Disease and Associated Disorders

Volume:

Volume 22, Number 4

Publisher:

, Pages 336-342

Type of Work:

Article | Post-print: After Peer Review

Abstract:

This study investigated the relationship between the vascular comorbidities of hypertension and hypercholesterolemia and the cognitive phenotype of Alzheimer’s disease (AD). Seventy four AD patients underwent objective measurement of blood pressure and serum cholesterol levels, and they received a detailed neuropsychological evaluation examining attention, memory, language, visuomotor/visuospatial skills, and executive functioning. Multiple regression analyses controlling for demographic variables, overall cognitive status, and the presence of diabetes/cardiac disease indicated that an increase in the number of vascular comorbidities, but not their severity, was associated with poorer verbal and visual recall, visuoconstructive and spatial analysis, verbal reasoning, and set shifting. The findings demonstrate that VCs are associated with specific aspects of cognitive functioning in AD patients. The mechanisms likely involve the effects of VCs on cerebrovascular disease including white matter disruption. The results highlight the importance of controlling these risk factors in patients who carry the diagnosis of AD.

Copyright information:

© 2008, © 2008 Lippincott Williams

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