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Author Notes:

Corresponding author: Stuart Zola, Ph.D. Yerkes National Primate Research Center, 954 N. Gatewood, Atlanta, GA 30329; e-mail: szola@rmy.emory.edu

Portions of this article were presented at the 34th annual meeting of the Society for Neuroscience, San Diego, California, October 2004.

Disclosure: The authors have reported no conflicts of interest.


Research Funding:

National Center for Research Resources : NCRR

National Institute on Aging : NIA

This work was supported by National Institute of Health Grant AG 025588, Yerkes Base Grant RR00165, Robert W. Woodruff Health Science Award from Emory University, Atlanta VAMC Merit Review award, and the Georgia Research Alliance.


  • mild cognitive impairment
  • Alzheimer's Disease
  • eye tracking
  • early diagnosis
  • visual paired comparison
  • preferential looking

Eye tracking during a visual paired comparison task as a predictor of early dementia


Journal Title:

American Journal of Alzheimer's Disease and Other Dementias


Volume 24, Number 3


, Pages 258-266

Type of Work:

Article | Post-print: After Peer Review


The authors present profiles of performance on a behavioral task (Visual Paired Comparison) using infrared eye tracking that could potentially be useful in predicting the onset of Alzheimer's Disease. Delay intervals of 2 sec and 2 min were used between the initial viewing of a picture and when the picture was displayed alongside a novel picture. Eye-tracking revealed that at the 2 second delay, 6 mild cognitively impaired patients (MCI), 15 matched control subjects (NC), and 4 neurological control subject's with Parkinson's Disease (PD) performed comparably, i.e., viewed the novel picture greater than 71% of the time. When the delay increased to 2 minutes, MCI patients viewed the novel picture only 53% of the time (p < .05), while NC and PD remained above 70%. These findings are consistent with the idea that the MCI patients did not remember well which picture was recently viewed. These findings demonstrate the usefulness of this task for assessing normal as well as impaired memory function.

Copyright information:

© 2009 The Author(s)

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