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Author Notes:

Corresponding author at: Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA. Fax: +1 404 727 9294. adeverg@emory.edu (A. Devergnas).

The authors thank Dr. Olivier Darbin for his work in the initial phases of the experiment, and Dr. Adriana Galvan for critically reading the manuscript.

The authors declare no competing financial interests.

Subjects:

Research Funding:

This study was supported by grants from the NIH/NINDS (R01-NS054976 and P50-NS071669) as well as an infrastructure grant from the NIH to the Yerkes Center (P51-RR165, now P51-OD11132).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • Parkinson's disease
  • Basal ganglia
  • Local field potential
  • Motor cortex
  • Sleep
  • Wakefulness
  • PRIMARY MOTOR CORTEX
  • DEEP BRAIN-STIMULATION
  • PRIMATE SUBTHALAMIC NUCLEUS
  • HIGH-FREQUENCY STIMULATION
  • BETA-OSCILLATIONS
  • GLOBUS-PALLIDUS
  • CEREBRAL-CORTEX
  • PATHOLOGICAL SYNCHRONIZATION
  • PHARMACOLOGICAL MODULATION
  • FUNCTIONAL CONNECTIVITY

Relationship between oscillatory activity in the cortico-basal ganglia network and parkinsonism in MPTP-treated monkeys

Tools:

Journal Title:

Neurobiology of Disease

Volume:

Volume 68

Publisher:

, Pages 156-166

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Parkinsonism is associated with changes in oscillatory activity patterns and increased synchronization of neurons in the basal ganglia and cortex in patients and animal models of Parkinson's disease, but the relationship between these changes and the severity of parkinsonian signs remains unclear. We examined this relationship by studying changes in local field potentials (LFPs) in the internal pallidal segment (GPi) and the subthalamic nucleus (STN), and in encephalographic signals (EEG) from the primary motor cortex (M1) in Rhesus monkeys which were rendered progressively parkinsonian by repeated systemic injections of small doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Observations during wakefulness and sleep (defined by EEG and video records) were analyzed separately. The severity of parkinsonism correlated with increases in spectral power at frequencies below 15.5. Hz in M1 and GPi and reductions in spectral power at frequencies above 15.6. Hz with little change in STN. The severity of parkinsonism also correlated with increases in the coherence between M1 EEG and basal ganglia LFPs in the low frequency band. Levodopa treatment reduced low-frequency activity and increased high-frequency activity in all three areas, but did not affect coherence. The state of arousal also affected LFP and EEG signals in all three structures, particularly in the STN. These results suggest that parkinsonism-associated changes in alpha and low-beta band oscillatory activity can be detected early in the parkinsonian state in M1 and GPi. Interestingly, oscillations detectable in STN LFP signals (including oscillations in the beta-band) do not appear to correlate strongly with the severity of mild-to-moderate parkinsonism in these animals. Levodopa-induced changes in oscillatory M1 EEG and basal ganglia LFP patterns do not necessarily represent a normalization of abnormalities caused by dopamine depletion.

Copyright information:

© 2014 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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