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Author Notes:

Correspondence should be addressed to A.A.A (pathaaa@emory.edu).

See publication for full list of author contributions.

The authors are grateful to Dr. Fawn Connor-Stroud for help with the cytobrush studies and to the veterinary staff and animal caretakers of the Yerkes National Primate Center of Emory University specially Ms. Stephanie Ehnert and her team.

The authors also graciously acknowledge the assistance of Dr. M. Piatak (NCI, NIH, Frederick, MD) for performing the ultra sensitive PCR analysis and Dr. Rupert Kaul/Dr. L. R. McKinnon (University of Toronto, Toronto, Canada) for sharing with us his finding on cervical brush analyses in Africa and advising us on how to proceed in adapting their human findings to our nonhuman primates.

We apologize to all the authors whose publications we failed to cite due to restrictions in the number of references we could include.

The authors declare no competing financial interests.

The findings in this report are those of the authors and do not necessarily reflect the views of the Centers for Disease Control and Prevention.

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Research Funding:

This work was supported by a grant from the NIH-NIAID AI-098628-01 (AAA) and OD 51POD1113 to the Yerkes National Primate Research Center.

Recombinant monoclonal antibodies were produced by the Nonhuman Primate Reagent Resource (NIAID, NIH contract # HHSN272200900037C).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Cell Biology
  • Medicine, Research & Experimental
  • Research & Experimental Medicine
  • T-CELL SUBSET
  • MAINTENANCE THERAPY
  • IMMUNE ACTIVATION
  • ALPHA-4-BETA-7
  • VEDOLIZUMAB
  • INDUCTION
  • DEPLETION
  • RECEPTOR
  • TRACT
  • CD4

Targeting alpha(4)beta(7) integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

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Journal Title:

Nature Medicine

Volume:

Volume 20, Number 12

Publisher:

, Pages 1397-1400

Type of Work:

Article | Post-print: After Peer Review

Abstract:

α4β7 integrin-expressing CD4+ T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4β7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIV mac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4+ T cell numbers were maintained in both the blood and the GALT. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques.

Copyright information:

© 2014 Nature America, Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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