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Author Notes:

Correspondence to: Johnna S. Temenoff.

The authors declare no conflict of interest.

Subject:

Research Funding:

The authors are supported by funding from the NIH (R01 AR062006) and NSF (DMR 1207045).

Keywords:

  • Science & Technology
  • Technology
  • Engineering, Biomedical
  • Materials Science, Biomaterials
  • Engineering
  • Materials Science
  • Glycosaminolgycan
  • Chemistry
  • Protein binding
  • Growth factor
  • Controlled release
  • FIBROBLAST-GROWTH-FACTOR
  • HYALURONIC-ACID HYDROGELS
  • CHONDROITIN SULFATE-E
  • CONJUGATED POLYMERIC MICELLE
  • BONE MORPHOGENETIC PROTEINS
  • MESENCHYMAL STEM-CELLS
  • HEPARIN-BASED HYDROGEL
  • CROSS-LINKED COLLAGEN
  • VESSEL WALL INJURY
  • DERMATAN SULFATE

Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery

Tools:

Journal Title:

Acta Biomaterialia

Volume:

Volume 10, Number 4

Publisher:

, Pages 1705-1719

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides that interact with a variety of positively charged growth factors. In this review article the effects of engineering GAG chemistry for molecular delivery applications in regenerative medicine are presented. Three major areas of focus at the structure-function-property interface are discussed: (1) macromolecular properties of GAGs; (2) effects of chemical modifications on protein binding; (3) degradation mechanisms of GAGs. GAG-protein interactions can be based on: (1) GAG sulfation pattern; (2) GAG carbohydrate conformation; (3) GAG polyelectrolyte behavior. Chemical modifications of GAGs, which are commonly performed to engineer molecular delivery systems, affect protein binding and are highly dependent on the site of modification on the GAG molecules. The rate and mode of degradation can determine the release of molecules as well as the length of GAG fragments to which the cargo is electrostatically coupled and eventually released from the delivery system. Overall, GAG-based polymers are a versatile biomaterial platform offering novel means to engineer molecular delivery systems with a high degree of control in order to better treat a range of degenerated or injured tissues.

Copyright information:

© 2013 Acta Materialia Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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