About this item:

179 Views | 52 Downloads

Author Notes:

Kristina Crothers, MD Associate Professor University of Washington Harborview Medical Center 325 9th Avenue PO Box Seattle, WA 98104 Office: (206) 744 9870 Fax: (206) 744.

Subjects:

Research Funding:

NIH/NHLBI R01-HL090342 (KC); K24-HL087713 (LH); HL090335 (LH); R01-HL090313 (PTD), R01-HL090483 (GK), R01-HL090316 (WNR), R01-HL090331 (BWT), R01-HL090339 (AM).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • pulmonary function
  • FEV1
  • DLCO
  • gas exchange
  • COPD
  • HIV/AIDS
  • HUMAN-IMMUNODEFICIENCY-VIRUS
  • COMBINATION ANTIRETROVIRAL THERAPY
  • MULTICENTER AIDS COHORT
  • VETERANS AGING COHORT
  • LUNG-FUNCTION
  • RESPIRATORY SYMPTOMS
  • NATIONAL SAMPLE
  • FUNCTION TESTS
  • US ADULTS
  • HAART ERA

HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity

Show all authors Show less authors

Tools:

Journal Title:

Journal of Acquired Immune Deficiency Syndromes

Volume:

Volume 64, Number 3

Publisher:

, Pages 271-278

Type of Work:

Article | Post-print: After Peer Review

Abstract:

INTRODUCTION: Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited. OBJECTIVES: To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals. METHODS: Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires. RESULTS: Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts <200 cells per microliter compared with those with CD4 cell counts ≥200 cells per microliter and to HIV-uninfected men. Respiratory symptoms of cough, phlegm and dyspnea were more prevalent in HIV-infected patients particularly those with abnormal pulmonary function compared with HIV-uninfected patients. CONCLUSIONS: HIV infection is an independent risk factor for reduced DLCO, particularly in individuals with a CD4 cell count below 200 cells per microliter. Abnormalities in pulmonary function among HIV-infected patients manifest clinically with increased respiratory symptoms. Mechanisms accounting for the reduced DLCO require further evaluation.

Copyright information:

Copyright © 2013 by Lippincott Williams & Wilkins.

Export to EndNote