About this item:

127 Views | 61 Downloads

Author Notes:

Ajit P. Yoganathan, Ph.D., The Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering, Associate Chair for Research, Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 232 Technology Enterprise Park (TEP), 387 Technology Circle, Atlanta, GA 30313, TEL: 404-894-2849, FAX: 404-385-1268, ajit.yoganathan@bme.gatech.edu.

The authors would like to acknowledge Procter & Gamble (P&G) for providing glycerin for our experiments; members of the Cardiovascular Fluid Mechanics Lab at Georgia Tech and Alexandra Low for their valuable inputs.


Research Funding:

This work was supported by a grant from the National Heart, Lung and Blood Institute (HL-07262).


  • Science & Technology
  • Technology
  • Engineering, Biomedical
  • Engineering
  • Particle image velocimetry (PIV)
  • Thrombosis
  • Blood damage
  • Mechanical heart valve (MHV)
  • Hinge flow
  • Fluid dynamics

Micro Particle Image Velocimetry Measurements of Steady Diastolic Leakage Flow in the Hinge of a St. Jude Medical (R) Regent (TM) Mechanical Heart Valve


Journal Title:

Annals of Biomedical Engineering


Volume 42, Number 3


, Pages 526-540

Type of Work:

Article | Post-print: After Peer Review


A number of clinical, in vitro and computational studies have shown the potential for thromboembolic complications in bileaflet mechanical heart valves (BMHV), primarily due to the complex and unsteady flows in the valve hinges. These studies have focused on quantitative and qualitative parameters such as velocity magnitude, turbulent shear stresses, vortex formation, and platelet activation to identify potential for blood damage. However, experimental characterization of the whole flow fields within the valve hinges has not yet been conducted. This information can be utilized to investigate instantaneous damage to blood elements and also to validate numerical studies focusing on the hinge's complex fluid dynamics. The objective of this study was therefore to develop a high-resolution imaging system to characterize the flow fields and global velocity maps in a BMHV hinge. In this study, the steady leakage hinge flow fields representing the diastolic phase during the cardiac cycle in a 23 mm St. Jude Medical regent BMHV in the aortic position were characterized using a two-dimensional micro particle image velocimetry system. Diastolic flow was simulated by imposing a static pressure head on the aortic side. Under these conditions, a reverse flow jet from the aortic to the ventricular side was observed with velocities in the range of 1.47-3.24 m/s, whereas low flow regions were observed on the ventricular side of the hinge with viscous shear stress magnitude up to 60 N/m2. High velocities and viscous shearing may be associated with platelet activation and hemolysis, while low flow zones can cause thrombosis due to increased residence time in the hinge. Overall, this study provides a high spatial resolution experimental technique to map the fluid velocity in the BMHV hinge, which can be extended to investigate micron-scale flow domains in various prosthetic devices under different hemodynamic conditions.

Copyright information:

© 2013 Biomedical Engineering Society.

Export to EndNote