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Author Notes:

Jamie Reilly, Ph.D., Temple University, Weiss Hall, Philadelphia, PA 19122, reillyj@temple.edu, Tel: (352) 672-4979.

We are grateful to Jeffrey Bennett;Hyejin Park; Alison Paris; Stephen Towler;and Michelle Benjamin for their assistance with anatomical tracing, brain normalization, and patient testing.

Subjects:

Research Funding:

This work was supported by US Public Health Service grants R01 DC013063 (JR); K23 DC010197 (JR); and R01 DC007387 (BC).

Keywords:

  • Social Sciences
  • Psychology
  • Psychology, Experimental
  • Semantic memory
  • Aphasia
  • Lesion correlation
  • Category specificity
  • Embodied cognition
  • DISTORTION-CORRECTED FMRI
  • SEMANTIC MEMORY EVIDENCE
  • CONCEPTUAL KNOWLEDGE
  • FUNCTIONAL ARCHITECTURE
  • SELECTIVE IMPAIRMENT
  • ALZHEIMERS-DISEASE
  • TEMPORAL CORTEX
  • MOTOR SYSTEM
  • ACTION WORDS
  • REPRESENTATION

Lesion symptom mapping of manipulable object naming in nonfluent aphasia: Can a brain be both embodied and disembodied?

Tools:

Journal Title:

Cognitive Neuropsychology

Volume:

Volume 31, Number 4

Publisher:

, Pages 287-312

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Embodied cognition offers an approach to word meaning firmly grounded in action and perception. A strong prediction of embodied cognition is that sensorimotor simulation is a necessary component of lexical-semantic representation. One semantic distinction where motor imagery is likely to play a key role involves the representation of manufactured artefacts. Many questions remain with respect to the scope of embodied cognition. One dominant unresolved issue is the extent to which motor enactment is necessary for representing and generating words with high motor salience. We investigated lesion correlates of manipulable relative to nonmanipulable name generation (e.g., name a school supply; name a mountain range) in patients with nonfluent aphasia (N = 14). Lesion volumes within motor (BA4, where BA = Brodmann area) and premotor (BA6) cortices were not predictive of category discrepancies. Lesion symptom mapping linked impairment for manipulable objects to polymodal convergence zones and to projections of the left, primary visual cortex specialized for motion perception (MT/V5+). Lesions to motor and premotor cortex were not predictive of manipulability impairment. This lesion correlation is incompatible with an embodied perspective premised on necessity of motor cortex for the enactment and subsequent production of motor-related words. These findings instead support a graded or "soft" approach to embodied cognition premised on an ancillary role of modality-specific cortical regions in enriching modality-neutral representations. We discuss a dynamic, hybrid approach to the neurobiology of semantic memory integrating both embodied and disembodied components.

Copyright information:

© 2014 Taylor & Francis.

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