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Author Notes:

Correspondence: Marjorie McCullough; marjorie.l.mccullough@emory.edu

Authors' Contributions: MLM conceived the study and drafted the manuscript.

VLS, HSF, EEC, and RMB made substantial contributions to the conception and design of the study.

MJT, CR and EEC made substantial contributions to the acquisition and interpretation of data.

WRD conducted the statistical analyses.

All authors were involved in revising the manuscript critically for important intellectual content.

All authors read and approved the final manuscript.

Disclosures: The authors declare that they have no competing interests.

Subjects:

Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study

Tools:

Journal Title:

Breast Cancer Research

Volume:

Volume 9, Number 1

Publisher:

, Pages R9-R9

Type of Work:

Article | Final Publisher PDF

Abstract:

Introduction Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. Methods We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. Results Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (≥902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; pinteraction = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. Conclusion We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype.

Copyright information:

© 2007 McCullough et al.; licensee BioMed Central Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 2.0 Generic License (http://creativecommons.org/licenses/by/2.0/).

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