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Author Notes:

Correspondence should be addressed to Kevin D. Bunting, kevin.bunting@emory.edu

Academic Editor: Cheng-Kui Qu

Subjects:

Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Tools:

Journal Title:

Advances in Hematology

Volume:

Volume 2012, Number 2012

Publisher:

, Pages 1-10

Type of Work:

Article | Final Publisher PDF

Abstract:

The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2. In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy. However, the one drug/one target approach is giving way to the concept of one drug/multiple target approach since few cancers are addicted to a single signaling molecule for survival and combination drug therapies can be problematic. In this paper, we cover recent findings on Gab multi-functionality, binding partners, and their role in hematological malignancy and examine the concept of Gab-targeted therapy.

Copyright information:

© 2012 Sheetal Verma et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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