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Author Notes:
Correspondence: Keith D. Wilkinson; Email: keith.wilkinson@emory.edu
Acknowledgments: We thank Robert Cohen for sharing his manuscript and helpful comments.
Disclosures: The authors declare that they have no competing interests.
Subjects:
Structure and recognition of polyubiquitin chains of different lengths and linkage
Abstract:
The polyubiquitin signal is post-translationally attached to a large number of proteins, often directing formation of macromolecular complexes resulting in the translocation, assembly or degradation of the attached protein. Recent structural and functional studies reveal general mechanisms by which different architectures and length of the signal are distinguished.
Copyright information:
© 2011 Faculty of 1000 Ltd
This is an Open Access work distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/).
