Associations between the SS variant of 5-HTTLPR and PTSD among adults with histories of childhood emotional abuse: Results from two African American independent samples

• Authors: Kate Walsh, Columbia University; Monica Uddin, Wayne State University; Richelo Soliven, Wayne State University; Derek E. Wildman, Wayne State University; Bekh Bradley-Davino, Emory University
• Journal Title: Journal of Affective Disorders
• Volume: Volume 161
• Publisher: Elsevier: 12 months | 2014-06-01, Pages 91-96
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.jad.2014.02.043
• Subjects: Health Sciences, Mental Health; Biology, Genetics
• Keywords: Science & Technology; Life Sciences & Biomedicine; Clinical Neurology; Psychiatry; Neurosciences & Neurology; PTSD; Child abuse; Gene-environment interaction; POSTTRAUMATIC-STRESS-DISORDER; SEROTONIN-TRANSPORTER-GENE; PARENTAL VERBAL ABUSE; TRAUMATIC EVENTS; RISK; GENOTYPE; POLYMORPHISM; DEPRESSION; MODERATION; SYMPTOMS

Abstract

Background: Prior studies have found that the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) interacts with stressful life events to increase general risk for PTSD, but this association has not extended to African American samples. Further, little is known about the effects of this interaction on specific PTSD symptom clusters, despite indications that clusters may have different biological substrates. The current study examined the interaction between exposure to childhood emotional abuse and 5-HTTLPR genotype on risk for PTSD symptom severity and severity of specific PTSD symptom clusters in two African American samples. Methods: Participants were 136 African American household residents from Detroit, MI and 546 African American patients recruited from waiting rooms in primary care clinics in Atlanta, GA. Participants reported emotional abuse exposure and PTSD symptom severity, and provided DNA for triallelic 5-HTTLPR genotyping. Analysis of covariance (ANCOVA) was used to examine main effects and interactions. Results: In both African American samples, 5-HTTLPR genotype modified the effect of emotional abuse on PTSD symptom severity. Participants with the low-expression SS genotype who were exposed to emotional abuse had significantly lower reexperiencing and arousal symptom severity scores. Limitations The DNHS genetic sample size was small, and abuse data were assessed retrospectively. Conclusions: The SS variant of 5-HTTLPR appears to buffer against developing the reexperiencing and arousal symptoms of PTSD in two independent African American samples exposed to childhood emotional abuse. Findings also highlight the importance of considering emotional abuse experiences in patients with suspected PTSD.