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Author Notes:

David L. Safranski, Tel: 1-404-249-9155, Fax:1-404-249-9158, david.safranski@medshape.com

D.L. Safranski is an employee of MedShape, Inc.; K. Gall is a consultant for MedShape, Inc.

Subjects:

Research Funding:

Authors would like to thank NIH for funding SBIR 1R43HL097437.

Keywords:

  • Science & Technology
  • Technology
  • Engineering, Biomedical
  • Materials Science, Biomaterials
  • Engineering
  • Materials Science
  • Mechanical properties
  • Glass transition temperature
  • Biodegradation
  • Acrylics
  • Biocompatibility
  • SHAPE-MEMORY POLYMER
  • THERMOMECHANICAL PROPERTIES
  • IN-VIVO
  • METHACRYLATE COPOLYMERS
  • HYDROXYALKYL ACRYLATE
  • SYNTHETIC HYDROGELS
  • INTERNAL-FIXATION
  • BONE
  • POLY(L-LACTIDE)
  • INVITRO

Semi-degradable poly(beta-amino ester) networks with temporally controlled enhancement of mechanical properties

Tools:

Journal Title:

Acta Biomaterialia

Volume:

Volume 10, Number 8

Publisher:

, Pages 3475-3483

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Biodegradable polymers are clinically used in numerous biomedical applications, and classically show a loss of mechanical properties within weeks of implantation. This work demonstrates a new class of semi-degradable polymers that show an increase in mechanical properties through degradation via a controlled shift in a thermal transition. Semi-degradable polymer networks, poly(β-amino ester)-co-methyl methacrylate, were formed from a low glass transition temperature crosslinker, poly(β-amino ester), and high glass transition temperature monomer, methyl methacrylate, which degraded in a manner dependent upon the crosslinker chemical structure. In vitro and in vivo degradation revealed changes in mechanical behavior due to the degradation of the crosslinker from the polymer network. This novel polymer system demonstrates a strategy to temporally control the mechanical behavior of polymers and to enhance the initial performance of smart biomedical devices.

Copyright information:

© 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Creative Commons License

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