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Author Notes:

Correspondence: Jessica B Spencer, Division of Reproductive Endocrinology & Infertility, Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA; Email: jbspenc@emory.edu

Authors' Contributions: JBS developed study design, analyzed data, statistical methods, and drafted the manuscript.

ABS analyzed data, performed statistical analysis and reviewed the manuscript.

SDC assembled the raw database, provided critical review and expertise.

DRS developed hypothesis, study design and reviewed manuscript.

All authors read and approved the final manuscript.

Disclosures: JBS, ASB and DRS declare they have no competing interests.

SDC serves on the Future Fertility Leaders Advisory Board Meeting for Merck & Co., Inc.


Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF


Journal Title:

Reproductive Biology and Endocrinology


Volume 8, Number 29


Type of Work:

Article | Final Publisher PDF


Background Administration of recombinant luteinizing hormone (rLH) in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of the follicular cohort and promote monofollicular development. Methods To determine if rLH in late follicular development had a negative impact on follicular growth and oocyte yield, IVF patients in our practice who received rFSH and rLH for the entire stimulation were retrospectively compared with those that had the rLH discontinued at least two days prior to hCG trigger. Results The two groups had similar baseline characteristics before stimulation with respect to age, FSH level and antral follicle count. However, the group which had the rLH discontinued at least two days prior to their hCG shot, had a significantly higher number of oocytes retrieved, including a higher number of MII oocytes and number of 2PN embryos. Conclusions When using rLH for controlled ovarian hyperstimulation, administering it from the start of stimulation and stopping it in the late follicular phase, at least two days prior to hCG trigger, may increase oocyte and embryo yield.

Copyright information:

©2010 Spencer et al; licensee BioMed Central Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 2.0 Generic License (http://creativecommons.org/licenses/by/2.0/).

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