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Author Notes:

Reprints: Dolly Aguilera, MD, 5455 Meridian Mark Suite 400, Atlanta, GA 30342 (dolly.aguilera@choa.org).

R.F.: Speakers Bureau for Novartis for Afinitor.

T.J.M.D.: Paid consultant for Novartis (2012)

The remaining authors declare no conflict of interest.

Subjects:

Research Funding:

R.C.C.: Received funding from NIH R01CA172392, a Scholar Award (St. Baldrick’s Foundation), Springboard Grant (Alex’s Lemonade Stand Foundation), and Research Grants (Childhood Brain Tumor Foundation, CURE Childhood Cancer Foundation, and the Children’s Center for Neuroscience Pilot Grant).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Hematology
  • Pediatrics
  • everolimus
  • SEGA
  • tuberous sclerosis
  • spinal cord
  • TUBEROUS SCLEROSIS
  • SIROLIMUS
  • PATIENT
  • TUMORS
  • MODEL

Response of Subependymal Giant Cell Astrocytoma With Spinal Cord Metastasis to Everolimus

Tools:

Journal Title:

Journal of Pediatric Hematology/Oncology

Volume:

Volume 36, Number 7

Publisher:

, Pages E448-E451

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Background: Brain subependymal giant cell astrocytomas (SEGAs) in patients with tuberous sclerosis have been reported to respond to everolimus.Methods: A 15-year-old male patient with intractable seizures and multiple SEGAs of the brain developed leptomeningeal enhancement and multiple metastatic, histologically confirmed SEGAs of the spinal cord. He received daily everolimus at a dose of 3 mg/m2 for 6 weeks, which was then increased to 6 mg/m2.Results: Magnetic resonance image of the brain and spine showed significant reduction in the size of SEGAs after 6 weeks of treatment. The patient has remained free of progression for 24 months. Additional benefits included: excellent seizure control, decrease in the size of cardiac rhabdomyomas, and improved quality of life.Conclusions: We describe a rare case of metastatic SEGA, which was successfully treated with everolimus.

Copyright information:

© 2013 by Lippincott Williams & Wilkins.

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