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Author Notes:

Correspondence to Guang-Uei Hung, MD, Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, 6 Lukon Road, Lukong Town, Changhua 505, Taiwan, Tel: +886 4 7073299; fax: +886 4 7073299; 106143@gmail.com.

Dr Ji Chen receives royalties from the sale of Emory Cardiac Toolbox with SyncTool.

For the remaining authors there are no conflicts of interest.


Research Funding:

This study was supported in part by a research grant from Show Chwan Memorial Hospital (RD100001) and an NIH grant (1R01HL094438, PI: Ji Chen, PhD).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Radiology, Nuclear Medicine & Medical Imaging
  • dyssynchrony
  • gated SPECT
  • phase analysis
  • thallium-201

Left-ventricular dyssynchrony evaluated by Tl-201 gated SPECT myocardial perfusion imaging: a comparison with Tc-99m sestamibi


Journal Title:

Nuclear Medicine Communications


Volume 34, Number 3


, Pages 229-232

Type of Work:

Article | Post-print: After Peer Review


BACKGROUND AND PURPOSE: Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has been validated as a reliable tool to assess left-ventricular (LV) mechanical dyssynchrony. The initial results were all confirmed from studies using technetium-99m (Tc-99m) sestamibi or tetrofosmin as the radiotracers. The purpose of this study was to evaluate the feasibility of phase analysis in thallium-201 (Tl-201) gated SPECT MPI. MATERIALS AND METHODS: Seventeen patients referred from a cardiology clinic for evaluation of coronary artery disease were studied. All patients underwent both Tl-201 and Tc-99m sestamibi gated SPECT MPI within 1 week. An additional 34 patients with Tl-201 gated SPECT and 22 patients with Tc-99m sestamibi gated SPECT, who had a low likelihood of coronary artery disease, normal LV function, and normal perfusion on MPI, were used as normal controls. LV dyssynchrony parameters, including phase standard deviation (PSD) and phase histogram bandwidth (PHB), were measured using a standard phase analysis tool and compared between Tl-201 and Tc-99m sestamibi images. RESULTS: The LV dyssynchrony parameters correlated well (r=0.93 for PSD and r=0.84 for PHB) between Tl-201 and Tc-99m sestamibi images. The dyssynchrony parameters of Tl-201 were significantly larger than those of Tc-99m sestamibi (PSD: 24.5±12.0 vs. 17.4±9.7, P<0.001; PHB: 74.7±35.5 vs. 50.6±25.0, P<0.001). In comparison with normal controls, Tl-201 and Tc-99m sestamibi images showed concordant results. CONCLUSION: LV dyssynchrony parameters correlated well between Tl-201 and Tc-99m sestamibi images, even though the values were significantly larger for Tl-201 than for Tc-99m sestamibi. Tl-201 images showed results similar to those of Tc-99m sestamibi in the diagnosis of LV dyssynchrony.

Copyright information:

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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