Cytosines do it, thymines do it, even pseudouridines do it - Base flipping by an enzyme that acts on RNA

• Authors: Xiaodong Cheng, Emory University; Robert M. Blumenthal, Medical College of Ohio
• Journal Title: Structure
• Volume: Volume 10, Number 2
• Publisher: Elsevier (Cell Press) | 2002-02-01, Pages 127-129
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/S0969-2126(02)00710-4
• Subjects: Chemistry, Biochemistry
• Keywords: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Biophysics; Cell Biology

Abstract

In the December 28, 2001 issue of Cell, Hoang and Ferré-D'Amaré report the structure of a tRNA pseudouridine synthase, showing the target uridine flipped out from the tRNA and confirming that base flipping is not limited to enzymes that act on DNA.