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Author Notes:

Correspondence: Steven L. Spitalnik, Department of Pathology and Cell Biology, 630 West 168th St, College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA ss2479@columbia.edu.

We are grateful to Ozaira Santana for clerical support in gathering the multiple references used in preparing this review.

In addition, we apologize to authors of any publications we did not include in this review because of space limitations.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Hematology
  • RBC antigens and antibodies
  • Transfusion reactions
  • Immuno-haematology
  • RED-BLOOD-CELLS
  • AUTOIMMUNE HEMOLYTIC-ANEMIA
  • RECEPTOR-MEDIATED PHAGOCYTOSIS
  • PRIMARY ANTIBODY-RESPONSES
  • COMPLEMENT-FIXING SITES
  • REGULATORY T-CELLS
  • BETA-GLOBIN GENE
  • FC-GAMMA
  • TRANSGENIC MICE
  • IN-VIVO

Use of mouse models to study the mechanisms and consequences of RBC clearance

Tools:

Journal Title:

Vox Sanguinis

Volume:

Volume 99, Number 2

Publisher:

, Pages 99-111

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.

Copyright information:

© 2010 International Society of Blood Transfusion.

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