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Author Notes:

Corresponding Author (current address): Itamar Ronen, Ph.D., Associate Professor, Department of Radiology and the C.J. Gorter Center for High Field MRI, Leidenn University Medical Center, Leiden, The Netherlands, Address: Albinusdreef 2, Radiology C3-Q, Leiden 2333 ZA, The Netherlands, Office: +31 71 526 5479, i.ronen@lumc.nl.

Conflict of Interest: None declared.


Research Funding:

This work was supported by NIH grants P01-AG000001,R21-AG02878 and P51-RR000165.

For international collaboration, author Jong-Min Lee has received support from the Korea Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korea government (MEST) [grant number R0A-2007-000-20068-0].


  • Science & Technology
  • Life Sciences & Biomedicine
  • Geriatrics & Gerontology
  • Neurosciences
  • Neurosciences & Neurology
  • Aging brain
  • Rhesus monkey
  • Gray matter
  • Cerebral cortex
  • Cortical surface modeling
  • Cortical thickness
  • LAYER 1
  • MRI

Age-related effects on cortical thickness patterns of the Rhesus monkey brain


Journal Title:

Neurobiology of Aging


Volume 33, Number 1


, Pages 200.e23-200.e31

Type of Work:

Article | Post-print: After Peer Review


The Rhesus monkey is a useful model for examining age-related as well as other neurological and developmental effects on the brain, because of the extensive neuroanatomical homology to the human brain, the reduced occurrence of neurological diseases such as Alzheimer's disease, and the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. In this study, cortical thickness measurements based on a cortical surface modeling technique were applied for the first time to investigate cortical thickness patterns in the rhesus monkey brain, and were used to evaluate regional age related effects across a wide range of ages. Age related effects were observed in several cortical areas, in particular in the somato-sensory and motor cortices, where a robust negative correlation of cortical thickness with age was observed, similar to that found in humans. In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions.

Copyright information:

© 2012 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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