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Author Notes:

Correspondence to Richard A. Kahn: rkahn@emory.edu

The authors thank Jonathan Goldberg (Memorial Sloan-Kettering Cancer Center) for providing coordinates of his ArfGAP structure and Eric Ortlund (Emory University) for help in the preparation of Fig. 1 B.

We also acknowledge the many contributions to the field that we were not able to specifically cite due to limits on the number of citations.

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Research Funding:

This work was performed with support from extramural grants (GM67226, GM68029, R.A. Kahn; National Institutes of Health GM59989, DA016347, R.T. Premont; AI-043208, M.L. Zapp) and that from the Intramural Program (P.A. Randazzo, H. Inoue) of the National Institutes of Health, Department of Health and Human Services as well as the American Heart Association (0655454U, R.T. Premont), and a grant from the Israel Science Foundation 448/04 (D. Cassel).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell Biology
  • GTPASE-ACTIVATING PROTEIN
  • ACTIN CYTOSKELETON
  • MEMBRANE CURVATURE
  • GIT FAMILY
  • GOLGI
  • COMPLEX
  • GAP
  • LOCALIZATION
  • REGULATORS
  • CLATHRIN

Consensus nomenclature for the human ArfGAP domain-containing proteins

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Journal Title:

Journal of Cell Biology

Volume:

Volume 182, Number 6

Publisher:

, Pages 1039-1044

Type of Work:

Article | Final Publisher PDF

Abstract:

At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the Arf-GAP domain.

Copyright information:

© 2008, The Rockefeller University Press

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