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Author Notes:

Corresponding author: Sen Li. School of Life Sciences, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China. senli@connect.hku.hk

Sen Li and Jiaxin Wang contributed equally to this study as first authors.

Conception or design: S.L.

Acquisition, analysis, or interpretation of data: S.L., J.W., B.Z.

Drafting the work or revising: S.L., X.L., Y.L.

Final approval of the manuscript: S.L., J.W., B.Z., X.L., Y.L.

No potential conflict of interest relevant to this article was reported.


Research Funding:

This study is supported by the National Natural Science Foundation of China (Grant No. 81703942), Science Fund for Distinguished Young Scholars in BUCM (Grant No. BUCM-2019-JCRC004) and BUCM research program (to Sen Li).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Endocrinology & Metabolism
  • Diabetes complications
  • Diabetes mellitus
  • Mortality
  • RISK

Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study

Journal Title:

Diabetes and Metabolism Journal


Volume 43, Number 3


, Pages 319-341

Type of Work:

Article | Final Publisher PDF


Background: To investigate whether diabetes contributes to mortality for major types of diseases. Methods: Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status. Results: Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer's disease-related mortality. Conclusion: The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease.

Copyright information:

© 2019 Korean Diabetes Association

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/).

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