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Author Notes:

Corresponding Author: Christa Payne, 1920 Briarcliff Road NE/Atlanta, Georgia 30062, office: 404.785.8426, fax: 404.785.9063, christa.payne@emory.edu

We thank the veterinary and animal husbandry staff at UTHSC-Houston for expert care and handling of the animals, the image core facility at the University of Texas M.D. Anderson Cancer Center for their support during the MR imaging and their expert assistance in neuroimaging scanning techniques in infant monkeys, the members of the Bachevalier lab for their help with the surgical procedures, Christopher Machado, PhD for his help with research design, data coding and rater reliabilities, and Nancy Bliwise, PhD for her assistance in the development of the data analysis protocol.

The authors declare no competing financial interests.

Subjects:

Research Funding:

Supported by grants MH-58846 and HD 3547 to JB, Autism Speaks Mentor-Based Predoctoral Fellowship; Grant number: 1657; Yerkes Base Grant NIH 00165, currently supported by the Office of Research Infrastructure Programs/OD P51OD11132; Center for Behavioral Neuroscience grant NSF IBN-9876754.

Keywords:

  • Science & Technology
  • Social Sciences
  • Life Sciences & Biomedicine
  • Developmental Biology
  • Psychology
  • commissure
  • Macaca mulatta
  • neurodevelopment
  • neuroimaging
  • nonhuman primate
  • rhesus macaque
  • structural
  • volumetric
  • AUTISM SPECTRUM DISORDER
  • INFANT RHESUS MACAQUES
  • WORKING-MEMORY
  • WILLIAMS-SYNDROME
  • MACACA-MULATTA
  • PREFRONTAL CORTEX
  • BRAIN-DEVELOPMENT
  • SEX-DIFFERENCES
  • ADULT MACAQUES
  • FRONTAL AREAS

An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions

Tools:

Journal Title:

Developmental Psychobiology

Volume:

Volume 59, Number 4

Publisher:

, Pages 495-506

Type of Work:

Article | Post-print: After Peer Review

Abstract:

This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week—2 years of age; eight additional infants (4 males) were scanned once at 1–4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months. Males and females had comparable patterns of CC maturation overall, but exhibited slight differences in the anterior and posterior segments, with greater increases in the isthmus for males and greater increases in the rostrum for females. The developmental changes are likely a consequence of varying degrees of axonal myelination, redirection, and pruning. In Experiment 2, animals with neonatal lesions of the amygdala (n = 6; 3 males) or hippocampus (n = 6; 4 males) were scanned at 1.5 years post-surgery and compared to scans of six control animals from Experiment 1. Whereas amygdala damage yielded larger rostral and posterior body segments, hippocampal damage yielded larger rostrum and isthmus. These differences demonstrate that early perturbations to one medial temporal lobe structure may produce extensive and long-lasting repercussions in other brain areas. The current findings emphasize the complexity of neural circuitry putatively subserving neurodevelopmental disorders such as autism spectrum disorder and Williams syndrome, which are each characterized by malformations and dysfunction of complex neural networks that include regions of the medial temporal lobe.

Copyright information:

© 2017 Wiley Periodicals, Inc.

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