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Author Notes:

Address for Correspondence: Barbara D. Boyan, Ph.D., Institute for Bioengineering and Bioscience, 315 Ferst Drive NW, Georgia Institute of Technology, Atlanta, GA 30332-0363, Phone: 404-385-4108, FAX: 404-894-2291, barbara.boyan@bme.gatech.edu.

Subjects:

Research Funding:

This research was supported by USPHS AR052102, and the ITI Foundation.

RAGI is partially supported by a fellowship from IFARHU-SENACYT.

Support for the work of TM, YC, and KHS was provided by the Air Force Office of Scientific Research (Dr. Charles Lee, program manager).

The PT and SLA disks were provided by Institut Straumann AG.

Keywords:

  • Science & Technology
  • Technology
  • Engineering, Biomedical
  • Materials Science, Biomaterials
  • Engineering
  • Materials Science
  • Nanotopography
  • Titanium oxide
  • Surface roughness
  • Bone
  • Implant
  • Osteoblasts
  • OSTEOBLAST-LIKE CELLS
  • TITANIUM SURFACE
  • IN-VITRO
  • GENE-EXPRESSION
  • IMPLANT SURFACES
  • NANOPHASE METALS
  • BONE-RESORPTION
  • OSSEOINTEGRATION
  • OSTEOCLASTS
  • TOPOGRAPHY

The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation

Tools:

Journal Title:

Biomaterials

Volume:

Volume 32, Number 13

Publisher:

, Pages 3395-3403

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of nanoscale roughness on cell response been considered. The aim of the present study was to develop a simple and scalable surface modification treatment that introduces nanoscale features to the surfaces of Ti substrates without greatly affecting other surface features, and to determine the effects of such superimposed nano-features on the differentiation and local factor production of osteoblasts. A simple oxidation treatment was developed for generating controlled nanoscale topographies on Ti surfaces, while retaining the starting micro-/submicro-scale roughness. Such nano-modified surfaces also possessed similar elemental compositions, and exhibited similar contact angles, as the original surfaces, but possessed a different surface crystal structure. MG63 cells were seeded on machined (PT), nano-modified PT (NMPT), sandblasted/acid-etched (SLA), and nano-modified SLA (NMSLA) Ti disks. The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which, in turn, indicates the potential for improved implant osseointegration in vivo.

Copyright information:

© 2011 Elsevier Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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