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Author Notes:

Corresponding Author: Jonathan H. Lass, MD, c/o Cornea Donor Study Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, Phone: (813) 975-8690; Fax: (813) 975-8761; cds@jaeb.org

Roy Beck, M.D., Ph.D., the Principal Investigator for the Cornea Donor Study, had full access to all the study data and take responsibility for the integrity of the data and the accuracy of the data analysis.

The following CDS Publications Committee members independently reviewed and approved this manuscript for submission: Christopher R. Croasdale, M.D., Mark D. Mifflin, MD, Joel Sugar, MD.

We would like to acknowledge M. Edward Medof, M.D., Ph.D. for his consultation on the relationship of gender and endothelial cell loss.

Subjects:

Research Funding:

Supported by cooperative agreements with the National Eye Institute, National Institutes of Health, Department of Health and Human Services EY12728 and EY12358.

Additional support provided by: Eye Bank Association of America, Bausch & Lomb, Inc., Tissue Banks International, Vision Share, Inc., San Diego Eye Bank, The Cornea Society, Katena Products, Inc., ViroMed Laboratories, Inc., Midwest Eye-Banks (Michigan Eye-Bank, Illinois Eye-Bank), Konan Medical Corp., Eye Bank for Sight Restoration, SightLife, Sight Society of Northeastern New York (Lions Eye Bank of Albany), Lions Eye Bank of Oregon.

Keywords:

  • baseline factors
  • endothelial cell loss
  • penetrating keratoplasty
  • moderate-risk condition
  • Fuchs' dystrophy
  • pseudophakic/aphickic corneal edema
  • Cornea Donor Study
  • endothelial cell density
  • graft
  • donor
  • surgery

Baseline Factors Related to Endothelial Cell Loss Following Penetrating Keratoplasty

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Journal Title:

Archives of Ophthalmology -New Series-

Volume:

Volume 129, Number 9

Publisher:

, Pages 1149-1149

Type of Work:

Article | Final Publisher PDF

Abstract:

Objective: To identify baseline (donor, recipient, operative) factors that affect endothelial cell loss following penetrating keratoplasty for a moderate-risk condition (principally Fuchs’ dystrophy or pseudophakic/aphakic corneal edema). Methods: In a subset (n=567) of Cornea Donor Study (CDS) participants, preoperative and postoperative endothelial cell density (ECD) were determined by a central reading center. Multivariate regression analyses were performed to examine which baseline factors correlated with ECD over time. Results: Larger grafts (p<0.001), younger donor age (p < 0.001) and female donor gender (p = 0.004) were significantly associated with higher ECD during follow up. Mean endothelial cell loss at 5 years was 68% for > 8 – 9 mm grafts, 75% for 7 - < 8 mm grafts and 74% for those grafts 8.0mm in diameter. Grafts from female donors experienced a 67% cell loss compared with a 72% cell loss among grafts from male donors. Method of tissue retrieval, donor cause of death, history of diabetes, and time from death to preservation or to surgery were not significantly associated with changes in ECD over time (n=567). Conclusions: Following penetrating keratoplasty for endothelial dysfunction conditions, larger donor graft size, younger donor age and female donor gender were associated with higher ECD over five years. This data warrants exploring the possibility that similar associations may exist following endothelial keratoplasty.

Copyright information:

©2011 American Medical Association. All rights reserved

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