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Author Notes:

Joshua W. Buckholtz: joshua.buckholtz@vanderbilt.edu.



  • Adolescent
  • Adult
  • Amphetamine-Related Disorders
  • Autoreceptors
  • Benzamides
  • Corpus Striatum
  • Dextroamphetamine
  • Dopamine
  • Female
  • Humans
  • Impulsive Behavior
  • Ligands
  • Male
  • Positron-Emission Tomography
  • Pyrrolidines
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Signal Transduction
  • Substantia Nigra
  • Tegmentum Mesencephali
  • Ventral Tegmental Area
  • Young Adult

Dopaminergic network differences in human impulsivity

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Journal Title:

Вестник Волгоградского государственног... / Science Journal of Volgograd State University. History. Area Studies. International Relations


Volume 329, Number 5991


, Pages 532-532

Type of Work:

Article | Post-print: After Peer Review


Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving. Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release.

Copyright information:

© 2019 American Association for the Advancement of Science. All rights reserved.

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