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Author Notes:

Joshua W. Buckholtz: joshua.buckholtz@vanderbilt.edu.

Subjects:

Keywords:

  • Adolescent
  • Adult
  • Amphetamine-Related Disorders
  • Autoreceptors
  • Benzamides
  • Corpus Striatum
  • Dextroamphetamine
  • Dopamine
  • Female
  • Humans
  • Impulsive Behavior
  • Ligands
  • Male
  • Positron-Emission Tomography
  • Pyrrolidines
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Signal Transduction
  • Substantia Nigra
  • Tegmentum Mesencephali
  • Ventral Tegmental Area
  • Young Adult

Dopaminergic network differences in human impulsivity

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Journal Title:

Вестник Волгоградского государственног... / Science Journal of Volgograd State University. History. Area Studies. International Relations

Volume:

Volume 329, Number 5991

Publisher:

, Pages 532-532

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving. Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release.

Copyright information:

© 2019 American Association for the Advancement of Science. All rights reserved.

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