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Author Notes:

A.K. (ami.klin@yale.edu); and W.J. (warren.jones@yale.edu).

A.K. and W.J. developed the initial idea and design of the study, interpreted data, wrote the final manuscript, and take full responsibility for the integrity of data and the accuracy of data analysis.

A.K. supervised participant characterization; W.J. supervised all technical aspects of experimental procedure, data acquisition, and analysis; P.G. contributed to initial development of AVS methods and data analysis; D.L., with W.J. and G.R., developed the final AVS methods; G.R., with W.J. and A.K., helped develop new animations for the 2nd experiment; W.J. created the figures.

A.K. and W.J. performed final revision of the manuscript for intellectual content.

We wish to thank the families of the children included in this study for their time and participation.

We would also like to thank F. Shic for conceptual discussions and thoughts on methods.

We would like to thank L. Dickholtz, A. Kord, L. Else and M. Campisi for their assistance in creating the biological motion stimuli.

We also wish to thank K. Carr, A. Blank, A. Bhatt, S. Shultz and K. Knoch for their help in this research project; and our colleagues K. Chawarska, R. Paul and F. Volkmar for conceptual discussions and for their contributions to the clinical characterization of the samples.

The authors declare that they have no competing financial interests.

Subjects:

Research Funding:

This work was supported by a grant from the National Institutes of Mental Health (U54-MH66494);by Autism Speaks (piloting of methods); and by the Simons Foundation (current methodological developments).

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • PERCEPTION
  • FACE
  • AREA
  • RECOGNITION
  • FIXATION
  • DEFICITS
  • INFANTS

Two-year-olds with autism orient to non-social contingencies rather than biological motion

Journal Title:

Nature

Volume:

Volume 459, Number 7244

Publisher:

, Pages 257-U142

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Typically developing human infants preferentially attend to biological motion within the first days of life. This ability is highly conserved across species and is believed to be critical for filial attachment and for detection of predators. The neural underpinnings of biological motion perception are overlapping with brain regions involved in perception of basic social signals such as facial expression and gaze direction, and preferential attention to biological motion is seen as a precursor to the capacity for attributing intentions to others. However, in a serendipitous observation, we recently found that an infant with autism failed to recognize point-light displays of biological motion, but was instead highly sensitive to the presence of a non-social, physical contingency that occurred within the stimuli by chance. This observation raised the possibility that perception of biological motion may be altered in children with autism from a very early age, with cascading consequences for both social development and the lifelong impairments in social interaction that are a hallmark of autism spectrum disorders. Here we show that two-year-olds with autism fail to orient towards point-light displays of biological motion, and their viewing behaviour when watching these point-light displays can be explained instead as a response to non-social, physical contingenciesphysical contingencies that are disregarded by control children. This observation has far-reaching implications for understanding the altered neurodevelopmental trajectory of brain specialization in autism.

Copyright information:

© 2009 Macmillan Publishers Limited. All rights reserved.

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